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Sodium valproate and valproic acid show up to reduce barbiturate metabolism; thus, barbiturate blood stages really should be monitored and ideal dosage changes created as indicated.

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pentobarbital will minimize the extent or impact of midazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will lower the level or impact of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Double brexpiprazole dose around 1-2 weeks if administered with a strong CYP3A4 inducer.

pentobarbital will lessen the extent or influence of nicardipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will lower the extent or result of temsirolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will decrease the level or impact of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

pentobarbital will reduce the extent or outcome of amiodarone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will decrease the level or outcome of doravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

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pentobarbital will lessen the level or result of dexamethasone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will minimize the level or influence of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.